This 350-page report details both the prices paid by biotechnology companies and prices charged by biopharmaceutical contract manufacturing organizations for large-molecule drug substance production. In addition, this report documents current prices for related services offered by the contract manufacturing organizations, including cell banking, cell-line development, process development, technology transfer, and regulatory support. This report provides the reader with over 225 detailed charts and tables covering industry trends, selected contract terms and prices. Prices are reported for both mammalian cell culture and microbial fermentation technologies at specific bioreactor tank sizes. In addition to production prices, this report also documents FTE rates paid and charged by major functional areas.